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Limitations of the Review and Research Gaps Despite providing an integrative and mechanistic overview of nutrient metabolism across the menstrual cycle, several limitations should be acknowledged

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It is important in the normal functioning of the nervous system via its role in the synthesis of myelin, and in the circulatory system in the maturation of red blood cells in the bone marrow

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Third, methodological differences, including the use of immortalized cell lines, animal tissues or primary organoids, to variations in barrier assays (TER versus flux of paracellular markers such as mannitol, dextran and inulin) can yield different outcomes