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Studies indicate that cells will make a glycolytic switch when NAD + demand is high and exceeds ATP demand, therefore skewing the NAD + use for this pathway 341

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

Because its a water-soluble vitamin, any excess that isnt used should be flushed from the body and not pose too much risk (not the case with fat-soluble vitamins like vitamin A)

Taken together, these factors stabilize HIF- and prevent it from undergoing ubiquitination by E3 ligases (von Hippel Lindau factor, VHL ) for proteasomal degradation

The Cu part is the copper, an essential trace element in the human body (and in all living things)

Schefter, Adam (April 18, 2013)