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Stays cold
10.1016/j.neuroscience.2016.06.050 33 DutraR
D.et al (2017)
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To date, at least 3 years after the last treated patient, the survival of the patients is 100%
In vitro, PDE5 expression or activity can be up- or down-regulated in response to nitric oxide and cGMP, but in animal models sildenafil did not affect PDE5 expression in the corporal smooth muscle
