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Ackland G, Grocott MP, Mythen MG

Ophthalmology 2018

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One of NAD+s primary functions is in energy metabolism, specifically through glycolysis and oxidative phosphorylation. These pathways allow cells to convert glucose and other nutrients into adenosine triphosphate (ATP), the cells main energy currency

Upon targeting efflux transporters, reprogramming cancer metabolism, inducing mitochondrial apoptosis, and synergizing with chemotherapeutic agents, berberine exhibits the multi-faceted nature of drug resistance