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In lab and clinical research, its been observed to activate fibroblasts (the cells that produce collagen), increase glycosaminoglycan synthesis (which helps skin retain water), modulate matrix metalloproteinases (MMPs, the enzymes that break down old tissue), and act as a copper cofactor in antioxidant pathways

doi: 10.1038/nrd3701

A responsible medical practice checks IGF-1 at baseline, fasting glucose, and a general metabolic panel before prescribing any GH secretagogue