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51 One significant challenge is the high rate of gastrointestinal adverse events associated with these compounds, which may be related to their pharmacokinetic properties and direct gastrointestinal irritation

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[Google Scholar] 82.Ruenzi M., Stolte M., Veljaca M., Oreskovic K., Peterson J., Ulcerative Colitis Study Group A multicenter, randomized, double blind, placebo controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis