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Repurpose of the antibiotic NFT as activator of Nrf2 could thus be a promising strategy for a transient and targeted activation of the endogenous antioxidant machinery

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HEPATOCYTE CELL DEATH MECHANISMS AFTER APAP TOXICITY The mode of cell death after APAP-induced liver injury was controversial initially, since a number of mechanistic steps in the process, such as mitochondrial Bax translocation, release of cytochrome c64,79,88, and nuclear DNA fragmentation32, were similar to that seen during apoptosis (Fig