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Cytokine crosstalk within the bone marrow microenvironment as a novel resistance mechanism of Bcl-2/Mcl-1 inhibitor resistance in AML

The microtubule inhibitor vinblastine drives TAMs toward the M1 phenotype by activating NF-B and Cyba-dependent ROS pathways, while promoting TFEB nuclear translocation to enhance lysosomal function

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It is not intended for diagnostic, therapeutic, or clinical applications

Zhao S, Konopleva M, Chang S, Xie Z, Andreeff M

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