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77 On the other hand, in two similar studies using a preclinical canine IVD degeneration model, the intradiscal delivery of either nonsteroidal (celecoxib, selective COX2 inhibitor) or steroidal antiinflammatory (triamcinolone acetonide) drug release by a microsphere platform was able to reduce NGF expression in the IVD

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TB-500s key mechanisms include: Actin sequestration: By binding G-actin (monomeric actin), TB-500 keeps it available for cell migration and wound repair rather than polymerizing prematurely into structural filaments

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