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Immune dysfunction in uremiaan update

5 For instance, SIRTs, found in different cellular compartments, cleave acetyl groups from lysine residues of histones or other proteins and break down NAD + to produce ADPR and nicotinamide

Additional limitations include a small sample size and case-control approach for the primary analysis

Together, these clinical findings suggest that glial metabolic dysfunction may contribute to age-related neurodegenerative disorders

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