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In a study, the G protein-coupled estrogen receptor 1 (Gper1) gene was completely deleted in Dahl salt-sensitive hypertensive rats using CRISPR/Cas9 technology, resulting in a Gper1 / rat model
Biochem Biophys Res Commun 307:308314
However, their effects are non-specific (Li X
Lane TF, Iruela-Arispe ML, Johnson RS, & Sage EH
