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The weight loss achieved with tirzepatide is substantial and well-documented in clinical trials, and there is no evidence that NAD+ supplementation meaningfully augments this effect

, Maulu S., Verdegem M., and AbdelTawwab M

The real cultural tipping point in my mind seems to have been around 2022, when the GLP-1s really blew up, says Turnock, who is researching the peptide boom

Rey F, Ottolenghi S, Zuccotti G et al (2022) Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects