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Increasing the felbamate dose to 2,400 mg/day increased the mean valproate peak concentrations to 133 mcg/mL (another 16% increase)
This has led to an increase in DILI, for which pathophysiology and management methods differ significantly from the past
In research discussion, this type of blend is framed as a multi pathway design, where each component maps to a different biology category that can be measured with standard lab
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