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Saengsin K, Sittiwangkul R, Chattipakorn SC, Chattipakorn N

Septic cardiomyopathy (SIC) In a model of LPS-mediated septic cardiomyopathy, some researchers revealed that LPS caused ferroptosis and septic cardiac injury by downregulating GPX4 protein levels and increasing COX-2 [93]

doi: 10.1016/S0140-6736(17)31222-9

The present study found increased DNA methyltransferases activity and gene expression of Dnmt1, 3a, 3b, and Tet (2 and 3)

AST-treated mice showed enhanced expression of liver cholesterol metabolism genes (LDL receptor, 3-hydroxy-3-methylglutaryl-CoA reductase, and sterol regulatory element-binding protein) and -oxidation-related genes (carnitine palmitoyltransferase-1 and acyl-CoA), but no significant changes in lipogenic gene expression [96]