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Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility

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The most effective prevention strategy combines adequate protein intake (1.0-1.2 grams per kilogram daily), comprehensive micronutrient supplementation from day one, gradual dose titration to moderate the rate of weight loss, maintaining a caloric floor, and baseline blood work to identify and correct pre-existing deficiencies

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The preponderance of pharmaceutical companies and CROs provides better execution in all trial phases