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I am so thankful that she is my healthcare provider

3-Hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), the rate-limiting enzyme of ketogenesis, is hypersuccinylated in the absence of SIRT5, but this modification of HMGCS2 inhibits its activity and reduces ketone body production (Rardin et al., 2013)

Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, et al

We are also grateful to Andrea Grostl Dietz, Stephanie von Holstein-Rathlou, Kristian Nygaard Mortensen, Andrew James Samson, Simon Sanggaard, Mauro DiNuzzo, Camilla Dall, Celia Johanne Kjrby Palner, Benjamin Travis Kress, Harlan Albert Mullins, and Pia Crine Christensen for critically reading the manuscript

Unlike the LRG1-induced Smad1/5/8 signaling, the endoglin is not required for LRG1-induced Smad2 signaling in fibroblasts

Acknowledgements The authors are also grateful to the staff of the Institutes of Advanced Technology, Department of Chemistry UPM for their help in this research, Institute of Bioscience (IBS/UPM) for technical assistance