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Furthermore, oxidative stress is one of the most known inducing factors of hepatic apoptosis [83]

Hyperglycemia exacerbates oxidative stress and inflammation, reducing nitric oxide (NO) bioavailability and impairing endothelial function

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Additionally, in mice with experimentally induced reduction in FGF21 expression there was an associated lipemia, reduced ketogenesis, and a resultant fatty liver

For example, disease-related acylcarnitines increase after overnight fasting but decrease by approximately 60% within two hours after a meal [176]