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Non-canonical independent defense systems In addition to the canonical GPX4/GSH axis, cells possess other parallel, GPX4-independent anti-ferroptotic pathways that provide additional layers of protection

Moreover, guidance on management of symptomatic and asymptomatic HA is variable

2009;32:E13E19

Recent evidence suggests that the role of the IGF pathway in EMT is more complex than previously thought

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However, chronic GH treatment carries substantial risks, including glucose intolerance, insulin resistance, diabetes, cancer, and cardiovascular complications