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Acknowledgements We would like to extend our sincere gratitude to the University of Torbat-e Jam for its generous financial and moral support, which enabled us to carry out this review article

Non-medicinal Ingredients: Lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, vegetable grade magnesium stearate (lubricant)

7:1034-1043 (2022) Acknowledgements This study was financially supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) (RS-2025-02218354) and by the R&D Program of MOTIE/KEIT (RS-2025-02307907)

The accumulation of reactive oxygen species in G6PD deficiency also leads to aberrant oxidation of the cysteine sulfhydryl groups in the globin proteins in hemoglobin

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Despite the therapeutic potential of the NRF2-BACH1 axis, very few BACH1 inhibitors, namely, heme, cannabidiol (CBD) and HPPE (N-(2-(2-hydroxyethoxy)ethyl)-1-methyl-2-((6-(trifluoromethyl)benzo[d]thiazol-2-yl)amino)-1H-benzo[d]imidazole-5-carboxamide have been tested in pre-clinical settings of neurodegenerative diseases up to date