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During the apoptotic process, signaling cascades are activated, leading to a controlled death, and avoiding the uncontrolled release of parasites into the surrounding environment ( 2.2 Survival strategies of Leishmania inside macrophages Leishmania has evolved sophisticated ways to resist the array of microbicidal mechanisms generated by the macrophage, namely the oxidative stress, the recruitment of other immune cells and the process of apoptosis

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The likelihood of recurrence depends on many factors, including the stage at initial diagnosis, the success of initial surgical cytoreduction, the velocity of CA-125 decline, and progression-free interval after primary therapy

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