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On the other hand, the reduction of monoamine neurotransmitters availability caused by reserpine can lead to negative side effects associated with depression, pain signal processing abnormality, cognition impairment, and motor activity alteration 32,33,34

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Protopanaxadiol (PPD) is a primary active component extracted from Panax ginseng C.A.Mey

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Clinical trials on -viniferin While in vitro studies highlight various biological activities of viniferin isomers, translating these findings into clinical applications requires rigorous testing in humans

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In this regard, using broad-spectrum PKC inhibitors, it has been shown that PKC blockade upregulated p-AMPK levels, resulting in increased levels of LC3-II formation and p62 degradation indicative of increased autophagy, which resulted in the protection against APAP hepatotoxicity (Saberi et al., 2014), thus complementing the JNK-dependent contribution of PKC in APAP hepatotoxicity described above

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Sweat, M.D

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Hamblett KJ, Kozlosky CJ, Siu S, Chang WS, Liu H, Foltz IN, et al

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