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Apoptosis, a conventional form of programmed cell death, is reciprocally suppressed by necroptosis: The apoptotic executor caspase-8 cleaves and inactivates RIPK1/RIPK3, key kinases involved in necroptosis (202)
This indicates that the therapeutic goal should shift from merely suppressing ROS levels to enhancing the body's adaptive capacity to fluctuating oxygen and ROS conditions

doi: 10.1073/pnas.1014697108
doi: 10.3390/pharmaceutics14030531
However, evidence of the efficacy of enhanced control of glycemia in preventing neuropathy is stronger in patients with type 1 diabetes than in those with type 2 diabetes (73)
