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However, their efficacy in vivo models has not been reported yet

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Therefore, although some oligonucleotide products targeting NNMT have shown effectiveness in vitro and in animal experiments, to date, no oligonucleotide products targeting NNMT have been used in clinical trials

Sigmoidal dose-response curves and reliable estimates of IC 50 values based on non-linear least-squares fitting to the available data could not be obtained since no significant inhibition of DNMT1 and PRMT3 was observed at the tested NNMT inhibitor concentrations (Table 3)

5-Amino-1MQ from Loti Labs is for in-vitro laboratory research and experimentation only

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