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The role of S-adenosylhomocysteine hydrolase in the control of biological methylations

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, Tan VY, Yarmolinsky J, Shihab HA, Timpson NJ, Evans DM, Relton C, Martin RM, Davey Smith G, Gaunt TR, Haycock PC

Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis inhibitor against septic acute kidney injury

Mechanistically, TSA ME upregulated H3K18ac and H4K8ac expression, downregulated excitotoxicity-related NMDAR1 protein and apoptosis-related Caspase-3 and concurrently promoted neuronal cytoskeletal protein MAP-2 expression (210)

Authors:Grim JM, Miles DR, Crockett EL, Journal:J Exp Biol PubMed ID:20086129 'Cold acclimation of ectotherms results typically in enhanced oxidative capacities and lipid remodeling, changes that should increase the risk of lipid peroxidation (LPO)