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A rare autosomal disorder, neutral lipid storage disease, is characterized by the accumulation of excess neutral lipids in multiple tissues and is associated with mutations in ATGL and CGI-58 genes that are involved in lipolysis [143]

In cases of treatment failure, patients may carry one or more drug-resistant variants, and resistance-associated substitutions (RASs) testing should be considered if retreatment is contemplated

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Furthermore, progressions with development of lentigo maligna melanoma were reported after completion of therapy