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CaP cells depend strongly on the AR NTDs ligand-independent transactivation domain AF1, which mediates also transcriptional activity of agonist- and antagonist-indifferent AR variants after acquired resistance to ADT, but to date cannot be effectively inhibited in clinic [45]

Regarding therapeutic applications, while both compounds support energy metabolism, their optimal uses differ significantly

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Ursini F, Heim S, Kiess M, et al

This review summarizes our knowledge on the peritoneum in the initial phase of PD, during the first 2 years and the alterations in function and morphology in long-term PD patients