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In sequence terms, that Cterminal block is exactly the kind of motif that enables membrane penetration, The region: ArgArgSerGlyGlyLysArgProProProArgArgArgGlnArgArgLysLysArgGlyOH` has all the hallmarks of a CPP: High local positive charge density Arginine is the key driver the guanidinium group forms bidentate hydrogen bonds with phosphate and sulfate groups on the cell surface (heparan sulfate proteoglycans, phospholipid headgroups)

Dose-dependent bioavailability and tissue distribution of the ATR inhibitor AZD6738 (ceralasertib) in mice

developed solid pyramidal microneedle (MN) arrays fabricated with silk fibroin protein tips encapsulating a stabilized HIV envelope trimer immunogen and adjuvant, supported on a dissolving polymer base, which was capable of implanting the vaccine-loaded silk tips upon brief skin application

Oxidative Stress and Therapeutic Approaches in HIV Dementia

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doi: 10.1007/s40520-020-01616-x