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Acknowledgments The authors would like to thank Vidal E and Banas JL, Department of Neonatology, KK Women's and Children's Hospital, Singapore, for preparing the figures

Patients with end-stage renal disease undergoing dialysis can develop a secondary carnitine deficiency due to the unrestricted loss of L-carnitine through the dialyser, and L-carnitine has been used for treatment of some patients during long-term haemodialysis