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3 linked pagesOpen original clinicaltrials-gov-aod-9604 Certain bulk drug substances for use in compounding may present significant safety risks U.S

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14 - 19 Also, there are very limited extension of the standard cytoprotectants effect from the stomach lesions to other organs lesions (liver, pancreas), 20 , 21 thus a quite limited cytoprotective and organoprotective therapeutic potential

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Individuals considering extended protocols should discuss this temporal limitation with healthcare providers and maintain appropriate monitoring throughout treatment

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The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions

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Wang H, Li L, Qin LL et al (2018) Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency

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