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The chronic activation of the type I IFN pathway is a hallmark of SLE and contributes to the dysregulation of immune responses in this disease [132]

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Ethics approval and consent to participate All mouse procedures in this study were approved by the Institutional Animal Care and Use Committee protocol approved by the Committee for Care and Use of Laboratory Animals at Dalian Medical University (AEE21038, A-GW)

A retrospective analysis of 731 incident cases of pulmonary arterial hypertension showed that GGT, AST to ALT ratio, and neutrophil to lymphocyte ratio (NLR) were reliable prognostic biomarkers at baseline and follow-up, with predictive power comparable to the gold standard for risk stratification of patients with pulmonary arterial hypertension [78]