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Polysaccharides, particularly -glucans, are among the most well-studied bioactive compounds in H

However, renal and liver toxicity remains a concern in clinical trials [214, 215]

In a study of Hairpoor (HRHp) heterozygous mice (an animal model of MUHH), HR overexpression in epithelial cells and keratinocytes was found to block the Wnt/-catenin signalling pathway by upregulating DKK1 expression during the growth phase, promoting the degenerative progression of hair follicles

Ishigami A, Kondo Y, Nanba R, Ohsawa T, Handa S, Kubo S, et al

Most participants achieve at least a 10% loss in body weight, while some see over 20% during the program

2.5.1 Multi-omics approaches and systems biology in Alzheimers research Recent advances in multi-omics technologiesincluding transcriptomics, metabolomics, proteomics, and spatial transcriptomicshave opened new avenues for elucidating the molecular mechanisms through which natural products influence AD pathogenesis (Ma et al., 2024a)