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In one clinical study it was posited that a single presentation of the peptide may boost hGH levels by over 60-fold compared to placebo

These findings should be overseen with glutamate as the major excitatory neurotransmitter in the central nervous system (i.e., cognitive functions such as learning and memory in the brain [200], the precursor of major inhibitory neurotransmitter GABA) but excitotoxic neuronal death as a direct result of high concentrations [201], and tight physiologic range that should be maintained [59]

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[DOI: 10.1186/1471-2288-5-13] [DOI] [PMC free article] [PubMed] [Google Scholar] Hrbjartsson 2013 Hrbjartsson A, Thomsen AS, Emanuelsson F, Tendal B, Hilden J, Boutron I, et al

The addition of semaglutide to this already high-risk group showed further b12 decline, but whether this represents a medication effect, dietary changes from additional appetite suppression, or natural progression of post-surgical deficiency remains unclear