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Following their recruitment, patients were given ID numbers, and both patients and investigators were blinded until the time of analysis, when data pooling necessitated unblinding

8 Scheme3, eq

Basel: SPS Publications (2005)

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

This hypothesis, while mechanistically plausible, requires further experimental validation

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