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Furthermore, the extent of modification of the putative regulatory thiol by persulfidation needs to be quantified, as low stoichiometries of modification can only be regulatory if they activate a gain-of-function of the modified protein

With the experience gained in producing ICs with HBsAg and influenza HA and their respective antibodies, appropriate ratios and methodologies for the manufacture of ICs can be standardized to fulfill the regulatory requirements for clinical application

Kim MP, Correa A, Moran C, Erasmus J, Hofstetter WL, Mehran RJ, Rice DC , Walsh GL, Vaporciyan AA, Swisher SG, Roth JA

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