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Stresul oxidativ contribuie la mbtrnirea prematur a esuturilor prin pierderea rezistenei i elasticitii acestora, la scderea activitii enzimatice, ct i n dezvoltarea diverselor forme de cancer (cauzat de mutaiile produse de radicalii liberi la nivelul ADN-ului celular, care determin activarea genelor oncogene i inactivarea genei oncosupresoare p53 [1]), n dezvoltarea bolilor cardiovasculare, bolilor inflamatorii, artritei, a fibrozei pulmonare sau a bolilor neurodegenerative precum Alzheimer i Parkinson

As defective activation of PPAR is involved in psoriasis development, PPAR agonists may be promising agents for treatment of psoriasis

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By improving the solubility, bioavailability, pharmacokinetics, and targeted delivery of these phytochemicals, nanoformulation technologies increase their therapeutic efficacy

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In this review, we explore the link between Vit B12 and PD in terms of physiopathology regarding dysfunctional neural pathways, neuropathological processes as well as reviewing the major clinical traits of Vit B12 deficiency in PD and Levodopa-mediated neuropathy