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Over the years, research has suggested that certain nutritional deficiencies, particularly Vitamin B12 and folic acid, might play a role in the onset or progression of vitiligo

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In parallel, advances in peptide chemistry and structural biology have enabled the design of aggregation inhibitors, receptor-selective neuropeptide analogues, and cell-penetrating or brain-targeted peptide conjugates that modulate key pathways, including proteostasis, insulin and incretin signaling, neurotrophic support, and microglial activation

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