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In contrast to what observed in treatment-nave IPF patients, serum from IPF patients treated with pirfenidone failed to induce the generation of ROS and collagen synthesis in HPASMC (Fig

These findings are consistent with those from a different study (Wancket et al., 2012), in which rats fed a diet rich in cocoa displayed raised basal levels of the MAPK phosphatases MKP-1 and MKP-3, preventing the cerebral peripheral flogosis caused by MAPK

Many of these pro-inflammatory mediators are regulated by nuclear factor-kappaB (NF-B) and mitogen-activated protein kinases (MAPKs), such as p38 MAPK

Graphene-based electrochemical aptasensors for paraquat detection in agricultural products

Cardiovasc Res 36:276281 Masaki I, Yonemitsu Y, Yamashita A, Sata S, Tanii M, Komori K, Nakagawa K, Hou X, Nagai Y, Hasegawa M et al (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2

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