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Preclinical models have demonstrated the potential of targeting the cGAS-STING axis and enhancing deoxyribonuclease 1-like 3 (DNase1L3) activity for the treatment of autoimmune diseases (19,45,46)

Acetylcholine attenuated TNF-alpha-induced intracellular Ca(2+) overload by inhibiting the formation of the NCX1-TRPC3-IP3R1 complex in human umbilical vein endothelial cells

[PMC free article] [PubMed] [Google Scholar] 187.Newman JC, Verdin E

Y., Jo, C., Suh, J
Wang J, Yu H, Dong W, Zhang C, Hu M, Ma W, et al

Mitochondria-regulating hydrogels extend the protective role by specifically targeting mitochondrial dysfunction, which is intricately linked to OA pathology (Lpez De Figueroa et al., 2015)