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Untargeted metabolomics: Hypothesis-generating experiment to measure all metabolites to see whats there

[DOI] [PubMed] [Google Scholar] 193.McPhillips HA, Stille CJ, Smith D, et al

They found that iron, ACSL4, and MDA levels increased with increasing reperfusion time, with concomitant decreases in GPX4 levels, and deferoxamine treatment significantly ameliorated myocardial injury [88]

However, individuals possessing loss of function polymorphisms in UGTs responsible for formation of major glucuronides may be subject to reduced clearance and possible flux through alternative routes than result in metabolites of greater concern

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