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2012), our observation that APAP decreased GJ abundance suggested that hepatocytes mount a defense against the spread of oxidative stress molecules within liver tissue during the early stages of APAP exposure by reducing the expression of Cx32 (and consequently GJs)

doi: 10.1021/cr200084z

Deykin described the cytoprotective function of P2X7 through activating AMPK-signaling pathway

In situations characterized by inflammation, specific cytokines, notably TNF-, IL-6, and IL-1, amplify leptin production by acting as potent stimulants for adipocyte activity

Cells were cultured at 37 C, 5% CO 2 and 21% O 2

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