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Safflower yellow, a flavonoid isolated from safflower, reduces endogenous cholesterol by decreasing the expression of mevalonate decarboxylase and APOE4 in the cortex, thereby improving learning and memory performance in AD mice (Lu et al., 2011)

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doi: 10.1186/gb-2012-13-11-179 201 ZhouRCzechBBrenneckeJSachidanandamRWohlschlegelJAPerrimonNet al

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Its action on both amphetamine salts (amphetamine and dextroamphetamine) allows for a broader range of effect compared to single-ingredient medications like dextroamphetamine alone