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IGF-1 LR3, or Long-R3-IGF-1, is a lab-made version of insulin-like growth factor-1

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Although intracellular ROS are necessary for regular function 46 , when they are present at excess levels, they can lead to intracellular stress and numerous bone disorders, including osteoporosis 47 and osteoarthritis 48

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Nutr Metab (Lond) 2010;7:30

In one network meta-analysis, Tirzepatide demonstrated a relative risk of adverse events of 2.78 compared to placebo moderate, and lower than more aggressive multi-agonists like Retatrutide (RR 4.10)