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Administration of vitamin B 12 to patients with elevated serum homocysteine levels has not been shown to reduce cardiovascular outcomes in high-risk patients or alter the cognitive decline of patients with mild to moderate Alzheimer disease

doi: 10.3389/fphar.2012.00119

Despite being one of the least studied lymphocyte populations in neuroimmune interactions, a few studies have reported the presence of natural killer (NK) cells and ILCs in CNS tissue under homeostatic conditions [110, 134, 135]

Patients should be instructed to clean the injection site with alcohol and allow it to dry before injection

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care

The majority of patients report an improvement in joint mobility
