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However, when glutamine metabolism is targeted with a single treatment, tumor cells will activate other signaling pathways or strengthen glutamine metabolism reprogramming to meet their energy demand, resulting in different degrees of drug resistance in tumor cells, thus restricting targeted glutamine metabolism therapy

Instead, microRNAs regulate gene expression by preventing translation of targeted protein-coding RNA, in effect, silencing specific parts of the genetic code

doi: 10.1371/journal.pgen.1000437

Calverley P, et al

According to Lee and colleagues, dietary restriction for 4 weeks in rodents resulted in increased BrdU- and NeuN-positive cells in the dentate gyrus, which indicates an increase in proliferation and neuronal differentiation, respectively [176, 177]

We express our gratitude to all institutions and researchers for sharing the code or data used in the study