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doi: 10.1016/j.neuint.2017.03.014 211 SouthonASzostakKAcevedoKMDentKAVolitakisIBelaidiAAet al

Oxidation via CYP2E1 (5-10%) - TOXIC Creates NAPQI (N-acetyl-p-benzoquinone imine)the dangerous toxic metabolite INCREASES by 80% during pregnancy NAPQI measured at 43% HIGHER in first trimester when fetal brain is most vulnerable NAPQI must be immediately neutralized by glutathione When glutathione is depleted, NAPQI causes cellular damage Crosses placenta and damages fetal brain The Perfect Storm During Pregnancy Research reveals dramatic shifts in how pregnant women metabolize acetaminophen: Safe sulfation pathway DECREASES by 33% Toxic oxidation pathway INCREASES by 80% Glutathione levels DROP by 36-87% (when you need it most) Result: 43% MORE toxic NAPQI formed in first trimester Even though glucuronidation increases, it CANNOT compensate for the massive increase in toxic metabolite production combined with dramatically reduced glutathione reserves

[181] Infections such as cellulitis and sepsis may result from lymphedema due to the dense protein rich nature of the lymphatic fluid and requires treatment with antibiotics

Vitamin B12 is a water-soluble vitamin

With an IV drip at home, you can enjoy the full benefits of the treatment in a safe, comfortable setting without the need to visit a clinic

Benfield, A.H