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We integrate these mechanisms with endothelial dysfunction, innate immune priming, ECM remodeling and barrier failure across cardiovascular, metabolic, neurodegenerative, oncologic, pulmonary, renal and critical-illness contexts, emphasizing crosstalk with RNS/RSS and iron metabolism as key modulators

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Glutathione is a sulfur-containing peptide made up of three amino acids: glutamic acid, cysteine and glycine