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Additionally, mRNA expression of iron response element binding protein 2, encodes a master regulator of iron metabolism), and CS (citrate synthase, regulating the mitochondrial fatty acid metabolism) was upregulated in both models, while ACSF2 ((acyl-CoA synthetase family member 2, regulating the mitochondrial fatty acid metabolism) was upregulated only in APPswe/PS1dE9 mice

Yet, individuals with pre-existing conditions may be at increased risk of serious adverse effects (including death) if one considers the possibility that large doses of supplemental vitamin E might interfere with medications, and possibly lower their efficacy or increase their toxicity (1)

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10.1016/j.neulet.2005.10.056 186 KondoriN

Amla pretreatment increased maximum OCR in the presence of t-BHP (113.7 9.7% and 120.6 10.0% that of basal OCR at 250 M and 500 M t-BHP, resp.)