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Although the mechanism that leads to the depletion of Th17 cells remains largely unknown, some of the proposed mechanisms include (i) a lack of HIV-inhibitory RNases in human Th17 cells leading to early, sustained depletion [59], (ii) decreased levels of IL-21-producing cells responsible for maintaining Th17 cells [60], and (iii) a depletion of CD103+ dendritic cells which promote Th17 differentiation [61]

1.2.3 LOAD subtypes and atypical variants Typical Amnestic AD: The classic presentation involves prominent memory loss due to early involvement of the hippocampus and medial temporal lobe structures (Bertoux et al., 2020

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