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Some medical conditions may also increase the risk of deficiency

Vitamin B12 deficiency, tumor necrosis factor-alpha, and epidermal growth factor: a novel function for vitamin B12

Peroxynitrit (ONOO): Entsteht aus der Reaktion von Stickstoffmonoxid (NO) mit Superoxid (O) und wird durch Glutathion entschrft

While this is less common with oral supplements, it is something to be aware of

However, there are also some examples where the reaction occurs spontaneously
Cobalt Allergy Potential Risks for Patients Patients with a cobalt allergy face several risks related to Vitamin B12 intake: Nutritional Deficiency : Avoiding Vitamin B12 due to allergy concerns can result in deficiency, leading to anaemia, neurological issues, and other health problems