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Although an association between enteropathies and psychiatric disorders has long been recognized, it has been suggested that gut microbes represent direct mediators of psychopathology via bidirectional communication paths between the central nervous system and the gastrointestinal tract [83]

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It should be noted that studies regarding the effect of different microbial taxa on inflammation reported in this section lead to the hypothesis of an effect also on Hcy levels, but studies investigating the direct effect of microbial bacteria on Hcy metabolism are few in number

Dadhania VP, Tripathi DN, Vikram A, Ramarao P, Jena GB (2010) Intervention of -lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: a study in rat intestine